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What we know about D-dimer value in COVID-19 ?

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Do you Know about D-dimer value

The Connection between D-dimer and the severity of COVID-19 is not clear to anyone because of this is totally new for everyone . The study was aimed to research the association between D-dimer levels and therefore the severity of COVID-19 supported a cohort study and meta-analysis also many other study use to know about the real facts.
Some basic conclusion was given by the study that, Patients with severe COVID-19 have a better level of D-dimer than those with non-severe disease, and D-dimer greater than 0.5 μg/ml is related to severe infection in patients with COVID-19.

D-miner value in Covid-19 

This is also necessary for designing clinical research studies and assessing the outcome of various ways of treatment for novel Corona Virus.
The role played by D-dimer relates to the high pro coagulate state in COVID-19, as shown by the remarkable decline in mortality when those with high D-dimer levels are treated with anti coagulation.
The current study focuses on evolving monitoring and interpretation standards for D-dimer levels in hospitalized patients.

D-Dimer Value to know 

As for all coagulopathies, treatment of the underlying condition is paramount. Experience so far suggests that COVID-19 infection infrequently results in bleeding despite abnormal coagulation parameters.
How is D-dimer generated?
The liver produces several important proteins involved within the coagulation process, one among which incorporates fibrinogen.
A single fibrinogen molecule is a symmetrical dimer that is made up of three pairs of three different poly peptide chains, which include a, b and g. Each of the intertwined poly peptide chains that comprise a single fibrinogen molecule is held together by D- sulfide bonds.
Methods to quantify D-dimer levels

Basics of D-Dimer

There are currently four major sorts of commercial assays which will be wont to measure D-dimer levels, of which include blood analysis, enzyme-linked immunosorbent assay (ELISA), enzyme-linked immunofluorescence assay (ELFA) and Latex-enhanced immunoturbidimetric assay.
Several studies have found the ELFA method to supply the very best sensitivity for detecting D-dimer levels; however, the specificity of this method is approximately 46%. Similar sensitivity to D-dimer levels of 94% and 93% are reported with the ELISA and Latex methods, respectively; however, these methods are also limited in their specificity capabilities that both average at 53%.
The D-dimer test is now routinely utilized in the first-line assessment of patients suspected of suffering venous thromboembolism (VTE), which may present as either deep vein thrombosis (DVT) or pulmonary embolism (PE).The human D-dimer protein may be a biopsy performed within the medical laboratory to diagnose thrombosis. While a negative human D-dimer result rules out thrombosis, a positive test result can indicate thrombosis or other underlying potential health problems.

D dimer normal lab values

·Less than 250 micro grams per liter (mcg/L) Less than 1.37 nano moles per liter (nmol/L) A low or normal d-dimer test result means that there is very little of the substance that’s released as a blood clot breaks up. Having little or no of this substance means a blood coagulation problem isn’t likely.

Reference

·World Health Organization. What we know about long-term effects of COVID-19. World Health Organization. Available from: https://www.who.int/docs/default-source/coronaviruse/risk-comms-updates/update-36-long-term-symptoms.pdf

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